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Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 297.00 | |
5 mg | In stock | $ 778.00 | |
10 mg | In stock | $ 1,230.00 |
Description | Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE. |
In vitro | Attenuating lymphocyte cytotoxicity co-cultured with U-87MG, sifalimumab is effective at concentrations ranging from 3 to 36 μg/well when applied for 72 hours[1]. |
In vivo | Treatment with sifalimumab at doses of 30 mg/kg (subcutaneous injection) and 3 μg/g demonstrates a therapeutic effect and attenuates lymphocyte infiltration[1]. |
Synonyms | MDX-1103, MEDI-545 |
Molecular Weight | N/A |
CAS No. | 1006877-41-3 |
store at low temperature
store at -80°C
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Sifalimumab 1006877-41-3 Immunology/Inflammation Neuroscience COX MDX-1103 MEDI-545 inhibitor inhibit