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DX3-213B

Name: DX3-213B
Brand: TargetMol
SKU: T63136
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63136Cas No. 2749555-66-4

DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM. DX3-213B blocks ATP production (IC50: 11 nM) and inhibits the growth of MIA PaCa-2 cells (GI50: 11 nM). DX3-213B can be used to study pancreatic cancer.

DX3-213B

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Purity: 99.85%

Catalog No. T63136Cas No. 2749555-66-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$619	In Stock	In Stock
50 mg	$896	In Stock	-
100 mg	$1,220	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$189	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

DX3-213B AI Summary

DX3-213B exhibits significant cytotoxicity against human MIA PaCa-2 and BXPC-3 cells, with IC50 values ranging from 9.1 to 50.0 nM. It potently inhibits oxidative phosphorylation, specifically targeting complex I, and reduces ATP production. The compound demonstrates good metabolic stability in both mouse and human liver microsomes. In vivo studies in CD-1 mice reveal moderate oral bioavailability, measurable plasma concentrations, and relatively short terminal elimination half-lives..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM. DX3-213B blocks ATP production (IC50: 11 nM) and inhibits the growth of MIA PaCa-2 cells (GI50: 11 nM). DX3-213B can be used to study pancreatic cancer.
Targets&IC50	OXPHOS complex I:3.6 nM

Chemical Properties

Molecular Weight	478.57
Formula	C₂₀H₂₈F₂N₂O₅S₂
Cas No.	2749555-66-4
Smiles	CC(C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)N1CCC[C@H](C1)C(=O)N1CCC(F)(F)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (235.08 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0896 mL	10.4478 mL	20.8956 mL	104.4779 mL
5 mM	0.4179 mL	2.0896 mL	4.1791 mL	20.8956 mL
10 mM	0.2090 mL	1.0448 mL	2.0896 mL	10.4478 mL
20 mM	0.1045 mL	0.5224 mL	1.0448 mL	5.2239 mL
50 mM	0.0418 mL	0.2090 mL	0.4179 mL	2.0896 mL
100 mM	0.0209 mL	0.1045 mL	0.2090 mL	1.0448 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc