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Sabatolimab

(Synonyms: NVP-MBG453, MBG453) Copy Product Info
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Synonyms: NVP-MBG453, MBG453

Catalog No. T76699 Copy Product Info
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Sabatolimab (MBG453), a humanized IgG4 (S228P) antibody targeting TIM-3, is a potent inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab has potential immunosuppressive activity and selectively binds to TIM-3 on immune cells and bone marrow cells.
Sabatolimab
Cas No. 2252262-24-9
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$178In StockIn Stock
5 mg$538In StockIn Stock
10 mg$913-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:> 95%
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Sabatolimab (MBG453), a humanized IgG4 (S228P) antibody targeting TIM-3, is a potent inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab has potential immunosuppressive activity and selectively binds to TIM-3 on immune cells and bone marrow cells.
Endotoxin<1.0 EU/mg
SynonymsNVP-MBG453, MBG453
Reactivity
Human
Verified Activity
Immobilized Human TIM-3/KIM-3/HAVCR2 Protein (His) (TMPY-01621) at 1 μg/mL (100 μL/well) can bind Sabatolimab. The EC50 is 5.85 ng/mL.
Sabatolimab
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetTIM-3/HAVCR2/CD366
Chemical Properties
Molecular Weight146.1 kDa
Cas No.2252262-24-9
Antibody Information
IsotypeHuman IgG4SP kappa
Recommended Isotype Control
Storage & Solubility Information
StorageStore at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: Sabatolimab chemical structure | Sabatolimab molecular weight