Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+. |
In vitro | Mycalolide-B, a macrolide antibiotic derived from a marine sponge, presents a potent cytotoxicity against L1210 murine leukemia cells with an IC 50 value ranging from 10-50 nM, attributed to its tris-oxazole structure. This compound effectively suppresses smooth muscle contractions and Ca2+-induced contractions in permeabilized smooth muscles without altering cytosolic Ca2+ levels or myosin light chain phosphorylation. Additionally, Mycalolide-B impedes superprecipitation and Mg2+-ATPase activity stimulated by Ca2+, alongside inhibiting ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1]. |
Molecular Weight | 1027.175 |
Formula | C52H74N4O17 |
CAS No. | 122752-21-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mycalolide B 122752-21-0 inhibitor inhibit