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Pomalidomide-5-OH (Synonyms: CC-17368, CC17368, CC 17368, 5-Hydroxy pomalidomide)

Name: Pomalidomide-5-OH
Brand: TargetMol
SKU: T30772
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T30772 Copy Product Info

Purity: 99.83%

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Pomalidomide-5-OH is the primary active metabolite of pomalidomide. Pomalidomide-5-OH acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN) and can be used to recruit the cereblon protein. Pomalidomide-5-OH can be linked to a protein ligand via a linker to form a PROTAC.

Pomalidomide-5-OH

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Catalog No. T30772

Synonyms CC-17368, CC17368, CC 17368, 5-Hydroxy pomalidomide

Cas No. 1547162-41-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$328	-	In Stock
25 mg	$552	-	In Stock
50 mg	$787	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:Green

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pomalidomide-5-OH is the primary active metabolite of pomalidomide. Pomalidomide-5-OH acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN) and can be used to recruit the cereblon protein. Pomalidomide-5-OH can be linked to a protein ligand via a linker to form a PROTAC.
Synonyms	CC-17368, CC17368, CC 17368, 5-Hydroxy pomalidomide

Chemical Properties

Molecular Weight	289.24
Formula	C₁₃H₁₁N₃O₅
Cas No.	1547162-41-3
Smiles	O=C1NC(=O)C(N2C(=O)C3=CC=C(O)C(N)=C3C2=O)CC1
Relative Density.	1.677 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.00 mg/mL (138.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4573 mL	17.2867 mL	34.5734 mL	172.8668 mL
5 mM	0.6915 mL	3.4573 mL	6.9147 mL	34.5734 mL
10 mM	0.3457 mL	1.7287 mL	3.4573 mL	17.2867 mL
20 mM	0.1729 mL	0.8643 mL	1.7287 mL	8.6433 mL
50 mM	0.0691 mL	0.3457 mL	0.6915 mL	3.4573 mL
100 mM	0.0346 mL	0.1729 mL	0.3457 mL	1.7287 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc