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Risankizumab

Catalog No. T76778 CAS 1612838-76-2

Synonyms: Risankizumab rzaa, SKYRIZI, ABBV 066, BI-655066

Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.

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Risankizumab, CAS 1612838-76-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 243.00
5 mg	In stock	$ 793.00
10 mg	In stock	$ 1,230.00

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Description	Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
Targets&IC50	IL-17:17 pM (cynomolgus), IL-17:2 pM (human), IL-23:10pM (kd,human), IL-23:10pM (kd,cynomolgus)
In vitro	With Kds <10 pM, Risankizumab (BI 655066) exhibits high affinity for human and cynomolgus IL23[3]. Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively[2].
In vivo	In mice, Risankizumab (BI 655066) inhibits IL23-induced ear swelling and cytokine production following a single intraperitoneal (i.p.) dosage of 1 mg/kg[2].

Synonyms	Risankizumab rzaa, SKYRIZI, ABBV 066, BI-655066
Molecular Weight	N/A
CAS No.	1612838-76-2

Storage

store at low temperature

store at -20°C

References and Literature

1. McKeage K, Duggan S. Risankizumab: First Global Approval. Drugs. 2019 Jun;79(8):893-900. 2. Singh S, et al. Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody. MAbs. 2015;7(4):778-91. 3. Andrea Chiricozzi, et al. Risankizumab for the treatment of moderate to severe psoriasis. Expert Opinion on Biological Therapy. Volume 19, 2019 - Issue 1

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Keywords

Risankizumab 1612838-76-2 Immunology/Inflammation IL Receptor Risankizumab rzaa SKYRIZI ABBV 066 BI-655066 inhibitor inhibit

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