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Gancotamab (Synonyms: MM-302, MM302)
Catalog No. T77017 Copy Product Info
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Gancotamab (MM-302) is a HER2-targeting polyethylene glycolated liposome that encapsulates adriamycin to facilitate delivery to HER2-overexpressing tumor cells while limiting exposure to non-target tissues, including the heart.Gancotamab has antitumor activity and may be used to study advanced HER2-positive breast cancer.
Gancotamab
Copy Product Info🥰Excellent
Catalog No. T77017
Synonyms MM-302, MM302
Gancotamab (MM-302) is a HER2-targeting polyethylene glycolated liposome that encapsulates adriamycin to facilitate delivery to HER2-overexpressing tumor cells while limiting exposure to non-target tissues, including the heart.Gancotamab has antitumor activity and may be used to study advanced HER2-positive breast cancer.
Gancotamab
Cas No. 1509928-00-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $163 | In Stock | In Stock | |
| 5 mg | $428 | In Stock | In Stock | |
| 10 mg | $679 | - | In Stock | |
| 25 mg | $987 | - | In Stock | |
| 50 mg | $1,380 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.7% (SDS-PAGE); 98.4% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Gancotamab (MM-302) is a HER2-targeting polyethylene glycolated liposome that encapsulates adriamycin to facilitate delivery to HER2-overexpressing tumor cells while limiting exposure to non-target tissues, including the heart.Gancotamab has antitumor activity and may be used to study advanced HER2-positive breast cancer. |
| In vitro | Gancotamab is a liposomal drug targeting HER2 that carries approximately 20,000 Doxorubicin molecules in its core and 45 single-chain anti-HER2 antibodies attached to its surface. [1] Gancotamab (0.5 μM; 72 hr treatment) promotes increased mortality in BT474-M3 and NCI-N87 cells. [1] Gancotamab (1 μM; 2-24 hrs) induces activation of p-p53 levels in BT474-M3 and NCI-N87 cells, but has no significant effect on p-Akt signaling. [1] |
| In vivo | Gancotamab (3 mg/kg; i.v. every 7 days; 3 doses) has a significant inhibitory effect on tumor growth and upregulates the expression of p-p53, a DNA damage marker. [1] |
| Synonyms | MM-302, MM302 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB2/HER2/CD340 |
| Molecular Weight | 25.79 kDa |
| Cas No. | 1509928-00-0 |
| Isotype | IgG1 |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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