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Sarafotoxin S6d
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Catalog No. TP2726Cas No. 1446991-36-1
Alias STX-b
Sarafotoxin S6d (STX-b) is a peptide toxin isolated from the venom of the Israeli burrowing asp. It induces various Electrocardiogram (ECG) changes such as myocardial ischemia and hyperkalemia. In rat aortas, Sarafotoxin S6d causes intense vasoconstriction dependent on extracellular calcium ions and exhibits positive inotropic effects in rat atria. This compound is useful for research into cardiovascular diseases.
Sarafotoxin S6d
Copy Product Info😃Good
Catalog No. TP2726Alias STX-bCas No. 1446991-36-1
Sarafotoxin S6d (STX-b) is a peptide toxin isolated from the venom of the Israeli burrowing asp. It induces various Electrocardiogram (ECG) changes such as myocardial ischemia and hyperkalemia. In rat aortas, Sarafotoxin S6d causes intense vasoconstriction dependent on extracellular calcium ions and exhibits positive inotropic effects in rat atria. This compound is useful for research into cardiovascular diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Storage & Solubility Information
| Description | Sarafotoxin S6d (STX-b) is a peptide toxin isolated from the venom of the Israeli burrowing asp. It induces various Electrocardiogram (ECG) changes such as myocardial ischemia and hyperkalemia. In rat aortas, Sarafotoxin S6d causes intense vasoconstriction dependent on extracellular calcium ions and exhibits positive inotropic effects in rat atria. This compound is useful for research into cardiovascular diseases. |
| In vivo | Sarafotoxin S6d, administered intravenously at dosages of 0.3, 1.0, and 3.0 nmol/kg, consistently produces a sustained pressor effect and a transient increase in pulse pressure. However, at a higher dosage of 5.0 nmol/kg, Sarafotoxin S6d initially raises the blood pressure, heart rate, and respiratory rate, only to precipitate a rapid decline in these parameters, leading to death within 10 minutes in most mice. At this dosage, there is also a significant elevation in K+ levels by 159%. Furthermore, plasma enzymes such as LDH, CPK, IP, and glucose levels show notable increases, with LDH rising by 60%, CPK by 91%, IP by 137%, and glucose by 80%. |
| Synonyms | STX-b |
| Molecular Weight | 2591.98 |
| Formula | C112H163N27O34S5 |
| Cas No. | 1446991-36-1 |
| Smiles | C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@]5(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@](NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@@H](N)CSSC2)[H])(CSSC5)[H])[H])[H])=O)CCC(N)=O)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=6C=7C(NC6)=CC=CC7 |
| Sequence | Cys-Thr-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Ile-Ile-Trp (disulfide bridge: Cys1-Cys15, Cys3-Cys11) |
| Sequence Short | CTCKDMTDKECLYFCHQDIIW (disulfide bridge: Cys1-Cys15, Cys3-Cys11) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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