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BChE/MAO-B-IN-2

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Catalog No. T212448

BChE/MAO-B-IN-2 is a dual inhibitor with excellent blood-brain barrier permeability, targeting BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM). It exhibits antioxidant properties, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 is applicable in Alzheimer's disease (AD) research.

BChE/MAO-B-IN-2

BChE/MAO-B-IN-2

😃Good
Catalog No. T212448
BChE/MAO-B-IN-2 is a dual inhibitor with excellent blood-brain barrier permeability, targeting BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM). It exhibits antioxidant properties, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 is applicable in Alzheimer's disease (AD) research.
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Product Introduction

Bioactivity
Description
BChE/MAO-B-IN-2 is a dual inhibitor with excellent blood-brain barrier permeability, targeting BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM). It exhibits antioxidant properties, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 is applicable in Alzheimer's disease (AD) research.
Targets&IC50
MAO-B:0.45 μM
In vitro
BChE/MAO-B-IN-2 (Compound 4a-S) demonstrates DPPH radical scavenging activity with an IC50 of 3.57 mM, exhibits antioxidant activity in the CUPRAC assay with an IC50 of 33 μM, and possesses superoxide anion scavenging capability with an IC50 of 24 μM. Furthermore, MAO-B-IN-48 (1-25 μM) is non-cytotoxic to HepG2 cells.
In vivo
Administering BChE/MAO-B-IN-2 (20 mg/kg, oral gavage, for one week) can alleviate cognitive dysfunction induced by AlCl3 in mice.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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