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BAY-4931

Name: BAY-4931
Brand: TargetMol
SKU: T67933
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67933Cas No. 423150-91-8

BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.

BAY-4931

🥰Excellent

Purity: 99.47%

Catalog No. T67933Cas No. 423150-91-8

BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$289	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock
500 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:99.47%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.
Targets&IC50	PPARγ(RT112-FABP4-NLucP cellular):0.17 nM, PPARγ (mouse):0.14 nM, PPARγ (human):0.40 nM, UM-UC-9 cells:3.4 nM
In vitro	Fractionation of culture extracts using RP-HPLC and LC-MS showed that samples containing Questin was toxic to the human A549 lung cell line.[1]

Chemical Properties

Molecular Weight	421.83
Formula	C₂₂H₁₆ClN₃O₄
Cas No.	423150-91-8
Smiles	N(C(=O)C1=CC(N(=O)=O)=CC=C1Cl)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (266.7 mM), Sonication and heating to 70℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3706 mL	11.8531 mL	23.7062 mL	118.5312 mL
5 mM	0.4741 mL	2.3706 mL	4.7412 mL	23.7062 mL
10 mM	0.2371 mL	1.1853 mL	2.3706 mL	11.8531 mL
20 mM	0.1185 mL	0.5927 mL	1.1853 mL	5.9266 mL
50 mM	0.0474 mL	0.2371 mL	0.4741 mL	2.3706 mL
100 mM	0.0237 mL	0.1185 mL	0.2371 mL	1.1853 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc