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(R,S)-Anatabine (tartrate) (2743-90-0 free base)

Name: (R,S)-Anatabine (tartrate) (2743-90-0 free base)
Brand: TargetMol
SKU: T23228
Rating: 4.5 (1 reviews)

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Catalog No. T23228

Alias (R,S)-Anatabine (tartrate)

Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.

(R,S)-Anatabine (tartrate) (2743-90-0 free base)

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Catalog No. T23228Alias (R,S)-Anatabine (tartrate)

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$98	2-4 weeks	2-4 weeks
10 mg	$173	2-4 weeks	2-4 weeks
50 mg	$760	2-4 weeks	2-4 weeks
100 mg	$1,327	2-4 weeks	2-4 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.
In vitro	In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal-like SHSY-5Y cells. (R,S)-Anatabine also dose-dependently inhibits NF-κB activation [1].
In vivo	In vivo: In a transgenic mouse model with AD, treatment with anatabine for 4 days remarkably lowered brain soluble Aβ1-40 and Aβ1-42 levels [1].
Synonyms	(R,S)-Anatabine (tartrate)

Chemical Properties

Molecular Weight	310.3
Formula	C₁₀H₁₂O₂·C₄H₆O₆
Smiles	OC(C(O)C(O)=O)C(O)=O.C1(C2=CN=CC=C2)CC=CCN1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (64.45 mM), Sonication is recommended.

Ethanol: ≤1 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2227 mL	16.1134 mL	32.2269 mL	161.1344 mL
5 mM	0.6445 mL	3.2227 mL	6.4454 mL	32.2269 mL
10 mM	0.3223 mL	1.6113 mL	3.2227 mL	16.1134 mL
20 mM	0.1611 mL	0.8057 mL	1.6113 mL	8.0567 mL
50 mM	0.0645 mL	0.3223 mL	0.6445 mL	3.2227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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