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Isatuximab

Catalog No. T38951 CAS 1461640-62-9

Synonyms: SAR-650984, hu38SB19, Isatuximab-irfc

Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has antitumor activity, antibody-dependent cytotoxicity, complement-dependent cytotoxicity, and antibody-dependent cytophagocytosis, which can directly induce apoptosis in the absence of crosslinking. Isatuximab has an inhibitory effect on CD38 extracellular enzyme activity, which is associated with many cellular functions.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Isatuximab, CAS 1461640-62-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 714.00
10 mg	In stock	$ 1,190.00

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Biological Description

Chemical Properties

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Description

In vitro

The combination of Isatuximab with Pomalidomide (an immunomodulatory drug) results in greater direct toxicity and lysis of CD38 multiple myeloma cells by effector cells compared with Isatuximab alone [2] .

Synonyms	SAR-650984, hu38SB19, Isatuximab-irfc
Molecular Weight	N/A
CAS No.	1461640-62-9

Storage

store at low temperature

store at -20°C

References and Literature

1. Dhillon S. Isatuximab: First Approval [published correction appears in Drugs. 2020 May 23;:]. Drugs. 2020;80(9):905-912. 2. Attal M, et al. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study [published correction appears in Lancet. 2019 Dec 7;394(10214):2072]. Lancet. 2019;394(10214):2096-2107.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isatuximab 1461640-62-9 Apoptosis Immunology/Inflammation CD38 SAR650984 SAR 650984 SAR-650984 hu38SB19 Isatuximab-irfc inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.