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JAB-3068

Name: JAB-3068
Brand: TargetMol
SKU: T39640
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39640Cas No. 2169223-48-5

Alias SHP2-IN-6

JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor exhibiting anticancer and antitumor properties, designed for research in breast, lung, and esophageal cancers.

JAB-3068

🥰Excellent

Purity: 99.6%

Catalog No. T39640Alias SHP2-IN-6Cas No. 2169223-48-5

JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor exhibiting anticancer and antitumor properties, designed for research in breast, lung, and esophageal cancers.

Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$129	In Stock
10 mg	$198	In Stock
25 mg	$378	In Stock
50 mg	$569	In Stock
100 mg	$795	In Stock

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Batch Information

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Purity:99.6%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor exhibiting anticancer and antitumor properties, designed for research in breast, lung, and esophageal cancers.
In vitro	JAB-3068 (SHP2-IN-6) is a potent PTPN11 and SHP2 inhibitor that blocks SHP2-mediated signaling, demonstrating potential anti-tumor activity[1].
Synonyms	SHP2-IN-6

Chemical Properties

Molecular Weight	476.54
Formula	C₂₂H₂₆F₂N₆O₂S
Cas No.	2169223-48-5
Smiles	S(C1=C2C(N(C(C)=O)CC2(F)F)=CC=C1)C=3C(N)=NC(=CN3)N4CCC5(CC4)[C@H](N)COC5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (209.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0985 mL	10.4923 mL	20.9846 mL	104.9230 mL
5 mM	0.4197 mL	2.0985 mL	4.1969 mL	20.9846 mL
10 mM	0.2098 mL	1.0492 mL	2.0985 mL	10.4923 mL
20 mM	0.1049 mL	0.5246 mL	1.0492 mL	5.2461 mL
50 mM	0.0420 mL	0.2098 mL	0.4197 mL	2.0985 mL
100 mM	0.0210 mL	0.1049 mL	0.2098 mL	1.0492 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc