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2'-O-Methylinosine (Synonyms: 2'-(o-Methyl)-inosine)

Name: 2'-O-Methylinosine
Brand: TargetMol
SKU: TNU0003
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TNU0003 Copy Product Info

Purity: 99.88%

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2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally active purine nucleoside analog with antihypertensive activity.

2'-O-Methylinosine

Copy Product Info

🥰Excellent

Catalog No. TNU0003

Synonyms 2'-(o-Methyl)-inosine

2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally active purine nucleoside analog with antihypertensive activity.

Cas No. 3881-21-8

Pack Size	Price	USA Stock	Global Stock
25 mg	$30	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally active purine nucleoside analog with antihypertensive activity.
In vitro	2'-O-Methylinosine effectively inhibits FrC6 virus reverse transcriptase activity in cell-free systems. [1]
In vivo	2'-O-Methylinosine (100 mg/kg, ip) has a significant antihypertensive effect in rats. [2]
Synonyms	2'-(o-Methyl)-inosine

Chemical Properties

Molecular Weight	282.25
Formula	C₁₁H₁₄N₄O₅
Cas No.	3881-21-8
Smiles	O(C)[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](CO)[C@H]1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (283.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5430 mL	17.7148 mL	35.4296 mL	177.1479 mL
5 mM	0.7086 mL	3.5430 mL	7.0859 mL	35.4296 mL
10 mM	0.3543 mL	1.7715 mL	3.5430 mL	17.7148 mL
20 mM	0.1771 mL	0.8857 mL	1.7715 mL	8.8574 mL
50 mM	0.0709 mL	0.3543 mL	0.7086 mL	3.5430 mL
100 mM	0.0354 mL	0.1771 mL	0.3543 mL	1.7715 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc