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FABPs ligand 6

Name: FABPs ligand 6
Brand: TargetMol
SKU: T62870
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62870Cas No. 2988135-14-2

Alias MF6

FABPs ligand 6 (MF6) is a selective inhibitor of FABP5 and FABP7 that reduces levels of oxidative stress in the mouse spinal cord as well as lipopolysaccharide-stimulated interleukin-1β and tumor necrosis factor α accumulation in primary astrocyte cultures.FABPs ligand 6 has a potent protective function in oligodendrocytes of EAE mice through FABP5 inhibition. mitochondria with a strong protective function.

FABPs ligand 6

🥰Excellent

Purity: 97.45%

Catalog No. T62870Alias MF6Cas No. 2988135-14-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$562	-	In Stock
25 mg	$1,090	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.45%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	FABPs ligand 6 (MF6) is a selective inhibitor of FABP5 and FABP7 that reduces levels of oxidative stress in the mouse spinal cord as well as lipopolysaccharide-stimulated interleukin-1β and tumor necrosis factor α accumulation in primary astrocyte cultures.FABPs ligand 6 has a potent protective function in oligodendrocytes of EAE mice through FABP5 inhibition. mitochondria with a strong protective function.
Targets&IC50	FABP7:20 nM (Kd), FABP5:874 nM (Kd)
In vitro	FABP ligand 6 has exhibited a high binding affinity for FABP5 (KD=874 nM) and FABP7 (KD=20 nM), but not for FABP3 (KD=1038 nM). [1] FABPs ligand 6 almost completely suppressed the upregulated oxidative stress levels and significantly decreased the number of 4-HNE-positive cells. [1] FABPs ligand 6-treated astrocytes, significantly attenuated IL-1b and TNF-a levels, indicating a suppressed inflammatory response. [1]
In vivo	EAE mice were orally administered FABPs ligand 6 (1 mg/kg), which is the maximum effective dose in brain ischemia 1 week before MOG immunisation of the EAE model. FABPs ligand 6 administration significantly reduced the severity of EAE. [1]
Synonyms	MF6

Chemical Properties

Molecular Weight	458.52
Formula	C₂₈H₂₇FN₂O₃
Cas No.	2988135-14-2
Smiles	O=C(O)CCCOC=1C=CC(F)=CC1C2=NN(C3=CC=C(C=C3)C(C)C)C(=C2)C=4C=CC=CC4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL(218.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1809 mL	10.9046 mL	21.8093 mL	109.0465 mL
5 mM	0.4362 mL	2.1809 mL	4.3619 mL	21.8093 mL
10 mM	0.2181 mL	1.0905 mL	2.1809 mL	10.9046 mL
20 mM	0.1090 mL	0.5452 mL	1.0905 mL	5.4523 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1809 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0905 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc