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Spiroxamine

Name: Spiroxamine
Brand: TargetMol
SKU: T36940
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T36940 Copy Product Info

Purity: 99.67%

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Spiroxamine is a tertiary amine fungicide and an inhibitor of δ14 reductase and δ8→δ7 isomerase. Spiroxamine inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines.

Spiroxamine

Copy Product Info

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Catalog No. T36940

Cas No. 118134-30-8

Pack Size	Price	USA Stock	Global Stock	Quantity
25 mg	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.67%

Resource Download

COA MS HNMR HPLC

Product Introduction

Spiroxamine AI Summary

Spiroxamine exhibits diverse bioactivity across multiple assays, indicating its multifunctional potential. It acts as an antagonist of thyroid hormone receptor beta signaling with a potency of 8912.5 nM, and also as an antagonist of androgen receptor signaling with a much higher potency of 12.6 nM. Additionally, the compound functions as an agonist in farnesoid X receptor signaling, displaying a potency of 8.9 nM. Moreover, Spiroxamine demonstrates significant fungitoxicity against various strains of Monilinia laxa, including highly and moderately fenhexamid-resistant strains, with EC50 values ranging from 2.9 to 12.0 ug/mL. Its effectiveness extends to wild-type Monilinia laxa, emphasizing its potential as a robust antifungal agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	297.48
Formula	C₁₈H₃₅NO₂
Cas No.	118134-30-8
Smiles	CCCN(CC)CC1COC2(CCC(CC2)C(C)(C)C)O1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform: Slightly soluble

DMSO: 50 mg/mL (168.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3616 mL	16.8079 mL	33.6157 mL	168.0785 mL
5 mM	0.6723 mL	3.3616 mL	6.7231 mL	33.6157 mL
10 mM	0.3362 mL	1.6808 mL	3.3616 mL	16.8079 mL
20 mM	0.1681 mL	0.8404 mL	1.6808 mL	8.4039 mL
50 mM	0.0672 mL	0.3362 mL	0.6723 mL	3.3616 mL
100 mM	0.0336 mL	0.1681 mL	0.3362 mL	1.6808 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc