BLK Protein, Human, Recombinant (His)

Name: BLK Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-00307
Rating: 4.5 (1 reviews)

(Synonyms: Tyrosine-Protein Kinase Blk, p55-Blk, BLK, B Lymphocyte Kinase) Copy Product Info

Synonyms: Tyrosine-Protein Kinase Blk, p55-Blk, BLK, B Lymphocyte Kinase

Catalog No. TMPJ-00307 Copy Product Info

Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).

Pack Size	Price	USA Stock	Global Stock
5 μg	$80	35 days	35 days
10 μg	$129	35 days	35 days
20 μg	$198	35 days	35 days
50 μg	$390	35 days	35 days
100 μg	$626	35 days	35 days
200 μg	$987	35 days	35 days
500 μg	$1,900	35 days	35 days
1 mg	$2,730	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
Species	Human
Expression System	E. coli
Tag	C-6xHis
Accession Number	P51451
Amino Acid	Gly2-Pro505
Construction	Gly2-Pro505
Protein Purity	Greater than 85% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 500 mM NaCl, 1 mM DTT, pH 7.4.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Proteins are shipped with blue ice.
Synonyms	Tyrosine-Protein Kinase Blk, p55-Blk, BLK, B Lymphocyte Kinase
Research Background

Chemical Properties

Molecular Weight

50-65 KDa (reducing condition)

Storage & Solubility Information

Storage

Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: BLK Protein, Human, Recombinant (His) chemical structure | BLK Protein, Human, Recombinant (His) molecular weight