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Inetetamab
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Catalog No. T78335
Inetetamab is a humanized monoclonal antibody targeting HER2 receptor domain IV, exhibiting antitumor activity through inducing pyroptosis in lung adenocarcinoma. It is used in studies of HER2-positive metastatic breast cancer.
Inetetamab
Inetetamab
😃Good
Catalog No. T78335
Inetetamab is a humanized monoclonal antibody targeting HER2 receptor domain IV, exhibiting antitumor activity through inducing pyroptosis in lung adenocarcinoma. It is used in studies of HER2-positive metastatic breast cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | In Stock | In Stock | |
| 5 mg | $753 | - | In Stock | |
| 10 mg | $1,230 | - | In Stock | |
| 25 mg | $1,830 | - | In Stock | |
| 50 mg | $2,480 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.54% (SEC-HPLC)
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| Description | Inetetamab is a humanized monoclonal antibody targeting HER2 receptor domain IV, exhibiting antitumor activity through inducing pyroptosis in lung adenocarcinoma. It is used in studies of HER2-positive metastatic breast cancer. |
| In vitro | Inetetamab is a novel anti-HER2 monoclonal antibody. In combination with cisplatin, inetetamab increases ROS levels by inhibiting HER2/AKT/Nrf2 signaling, thereby triggering NLRP3/caspase-1/GSDMB mediated pyroptosis. Synergistically enhance the anti-tumor efficacy of LUAD cells. [1] |
| In vivo | Inetetamab (20 mg/kg intraperitoneally injected) showed antitumor effects in JIMT-1 xenograft mouse models. Inetetamab (20 mg/kg intraperitoneally injected) in combination with Pyrotinib or Cyclophosphamide demonstrated significant antitumor effects in JIMT-1 and NCI-N87 xenograft mouse models. [2] |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB2/HER2/CD340 |
| Molecular Weight | 145.1 kDa |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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