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SJM-3
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Catalog No. T38621Cas No. 1234977-97-9
SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.
SJM-3
🥰Excellent
Catalog No. T38621Cas No. 1234977-97-9
SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface. |
| In vitro | SJM-3 interacts with the high-affinity benzodiazepine binding site located at the α+/γ- subunit interface, yet it exerts its pharmacological effects via a presumably different site within the transmembrane domain. Its binding affinity at wild type receptors is measured through the displacement of [3H]-Flunitrazepam and [3H]-Ro15-1788, revealing a K i for SJM-3 of 218±70 nM and 242±38 nM, respectively[1]. |
| Molecular Weight | 354.4 |
| Formula | C18H15FN4OS |
| Cas No. | 1234977-97-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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