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Domagrozumab (Synonyms: PF-06252616, PF06252616)
Catalog No. T82534 Copy Product Info
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Domagrozumab (PF-06252616) is a humanized monoclonal antibody targeting myostatin, used in studies of muscle wasting diseases.
Domagrozumab
Copy Product Info🥰Excellent
Catalog No. T82534
Synonyms PF-06252616, PF06252616
Domagrozumab (PF-06252616) is a humanized monoclonal antibody targeting myostatin, used in studies of muscle wasting diseases.
Domagrozumab
Cas No. 1629605-31-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | - | In Stock | |
| 5 mg | $949 | - | In Stock | |
| 10 mg | $1,290 | - | In Stock | |
| 25 mg | $1,890 | - | In Stock | |
| 50 mg | $2,580 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.83% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Domagrozumab (PF-06252616) is a humanized monoclonal antibody targeting myostatin, used in studies of muscle wasting diseases. |
| In vitro | Domagrozumab is a humanized monoclonal antibody that neutralizes circulating cytokines, thereby preventing receptor activation. Domagrozumab inhibited human myostatin signaling activity with KD = 2.6 pM and IC50 < 1 nM. [1] |
| In vivo | Non-human primates (NHP) treated with Domagrozumab (10 or 30 mg/kg) showed dose-dependent increases in lean body mass and muscle volume, and increased circulating levels of myostatin. [1] |
| Synonyms | PF-06252616, PF06252616 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Siglec-3/CD33 |
| Molecular Weight | 143.96 kDa |
| Cas No. | 1629605-31-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
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