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2-oxo Clopidogrel

Name: 2-oxo Clopidogrel
Brand: TargetMol
SKU: T36222
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36222Cas No. 109904-27-0

Alias (±)-SR-121683, (±)-2-Oxo clopidogrel

2-oxo Clopidogrel((±)-SR-121683)) is a drug metabolite and thiolactone intermediate of Clopidogrel, which is catalyzed by hepatic cytochrome P450 (P450) enzymes via CYP3A oxidation, and is capable of further post hydrolysis to the active metabolite CAM.Clopidogrel is an antithrombotic pro-drug.

2-oxo Clopidogrel

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Catalog No. T36222Alias (±)-SR-121683, (±)-2-Oxo clopidogrelCas No. 109904-27-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	2-oxo Clopidogrel((±)-SR-121683)) is a drug metabolite and thiolactone intermediate of Clopidogrel, which is catalyzed by hepatic cytochrome P450 (P450) enzymes via CYP3A oxidation, and is capable of further post hydrolysis to the active metabolite CAM.Clopidogrel is an antithrombotic pro-drug.
Synonyms	(±)-SR-121683, (±)-2-Oxo clopidogrel

Chemical Properties

Molecular Weight	337.82
Formula	C₁₆H₁₆ClNO₃S
Cas No.	109904-27-0
Smiles	O=C1SC2C(=C1)CN(CC2)C(C(=O)OC)C=3C=CC=CC3Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 5 mg/mL (14.8 mM), Sonication and heating are recommended.

DMSO: 200 mg/mL (592.03 mM), Sonication and heating are recommended.

DMF:PBS (pH 7.2) (1:20): < 1 mg/mL, insoluble, Sonication is recommended.

DMF: 10 mg/mL (29.6 mM), Sonication and heating are recommended.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9602 mL	14.8008 mL	29.6016 mL	148.0078 mL
5 mM	0.5920 mL	2.9602 mL	5.9203 mL	29.6016 mL
10 mM	0.2960 mL	1.4801 mL	2.9602 mL	14.8008 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1480 mL	0.7400 mL	1.4801 mL	7.4004 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0592 mL	0.2960 mL	0.5920 mL	2.9602 mL
100 mM	0.0296 mL	0.1480 mL	0.2960 mL	1.4801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc