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Golexanolone
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Catalog No. T25458Cas No. 2089238-18-4
Alias GR-3027, Golexanolonum, Golexanolona
Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy.
Golexanolone
Copy Product Info🥰Excellent
Purity: 99.99%
Catalog No. T25458Alias GR-3027, Golexanolonum, GolexanolonaCas No. 2089238-18-4
Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | In Stock | In Stock | |
| 5 mg | $722 | In Stock | In Stock | |
| 10 mg | $987 | In Stock | In Stock | |
| 25 mg | $1,520 | In Stock | In Stock | |
| 50 mg | $1,980 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.99%
ee:99.60%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy. |
| In vitro | In the absence of agonist (i.e., GABA, 0), the THDOC-mediated outward current excursion was significantly reduced when Golexanolone(GR3027) concentration was incrementally increased (0.03-3 µM, Fig. 2A), with an IC50 = 344 nM and Imax -33%. In addition, analysis of the AUC and peak current amplitude of the GABA-mediated response showed a concentration-dependent decrease in both parameters (IC50 = 341 nM, Imax -35% for AUC; IC50 = 563 nM, Imax -37% for peak current amplitude; n = 4-14, 95% confidence intervals;) The data suggest that the effects of Golexanolone(GR3027) on the THDOC-mediated α5β3γ2L GABAA channel activation.[2] |
| In vivo | In a toxicity study using doses of 50 and 100 mg/kg/day to evaluate oral administration of Golexanolone(GR3027) in rats, no toxicity was observed at 100 mg/kg/day.[1] |
| Synonyms | GR-3027, Golexanolonum, Golexanolona |
| Molecular Weight | 329.48 |
| Formula | C21H31NO2 |
| Cas No. | 2089238-18-4 |
| Smiles | C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)\C(=N\O)\CC4)[H])(CC[C@]1(C[C@@](C#C)(O)CC2)[H])[H])[H] |
| Relative Density. | 1.22 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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