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Refanezumab
(Synonyms: GSK249320, GSK 249320) Copy Product Info
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Synonyms: GSK249320, GSK 249320
Catalog No. T77388 Copy Product Info
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Refanezumab (GSK249320) is a humanized monoclonal antibody that crosses the blood-brain barrier (BBB) and targets myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab is used in the study of neurological and cardiovascular diseases.
Cas No. 1233953-61-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $360 | - | In Stock | |
| 5 mg | $1,120 | - | In Stock | |
| 10 mg | $1,770 | - | In Stock | |
| 25 mg | $3,360 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.2% (SDS-PAGE); 98.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Refanezumab (GSK249320) is a humanized monoclonal antibody that crosses the blood-brain barrier (BBB) and targets myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab is used in the study of neurological and cardiovascular diseases. |
| In vivo | Male Sprague Dawley rats were administered 10 mg/kg Refanezumab intravenously starting 24 hours after stroke onset and repeated weekly for a total of 6 doses. The results showed that this treatment resulted in significant improvements in neurologic scores and step tests. Refanezumab was able to penetrate the damaged area and had some positive impact on functional recovery within 24 hours of stroke. [1] |
| Synonyms | GSK249320, GSK 249320 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Siglec-4a/MAG |
| Molecular Weight | 148.28 kDa |
| Cas No. | 1233953-61-1 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Refanezumab chemical structure | Refanezumab in vivo | Refanezumab molecular weight
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