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(S)-SNAP5114

Name: (S)-SNAP5114
Brand: TargetMol
SKU: T16831
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16831Cas No. 157604-55-2

(S)-SNAP5114 is a selective inhibitor of GABA transport, exhibiting IC50 values of 5 μM for hGAT-3 and 21 μM for rGAT-2, and possesses anticonvulsant properties.

(S)-SNAP5114

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Purity: 98.20%

Catalog No. T16831Cas No. 157604-55-2

(S)-SNAP5114 is a selective inhibitor of GABA transport, exhibiting IC50 values of 5 μM for hGAT-3 and 21 μM for rGAT-2, and possesses anticonvulsant properties.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$44	-	In Stock
10 mg	$71	-	In Stock
25 mg	$163	-	In Stock
50 mg	$237	-	In Stock
100 mg	$343	-	In Stock
200 mg	$469	-	In Stock
1 mL x 10 mM (in DMSO)	$47	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.20%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR HPLC HPLC

Product Introduction

(S)-SNAP5114 AI Summary

(S)-SNAP5114 exhibits bioactivity as an inhibitor of various GABA transporters, specifically GAT1, GAT2, GAT3, and GAT4, across different species including human and mouse models. It shows varying levels of inhibition for each transporter; the most potent inhibition is observed for GAT3 (IC50 = 1080.0 nM in bovine brain stem), followed by GAT4 (IC50 = 1548.82 nM in mice), with moderate inhibition of GAT2 (IC50 = 21000.0 nM in rats) and weaker inhibition of GAT1 (IC50 = 85113.8 nM in mice). Additionally, (S)-SNAP5114 shows a selectivity index ratio, indicating a preference for GAT3 over other transporters. This suggests potential applications for the compound in modulating GABAergic neurotransmission..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(S)-SNAP5114 is a selective inhibitor of GABA transport, exhibiting IC50 values of 5 μM for hGAT-3 and 21 μM for rGAT-2, and possesses anticonvulsant properties.
Targets&IC50	GAT-2 (rat):21 μM, GAT-3 (human):5 μM

Chemical Properties

Molecular Weight	505.6
Formula	C₃₀H₃₅NO₆
Cas No.	157604-55-2
Smiles	COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
Relative Density.	1.175 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (178.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9778 mL	9.8892 mL	19.7785 mL	98.8924 mL
5 mM	0.3956 mL	1.9778 mL	3.9557 mL	19.7785 mL
10 mM	0.1978 mL	0.9889 mL	1.9778 mL	9.8892 mL
20 mM	0.0989 mL	0.4945 mL	0.9889 mL	4.9446 mL
50 mM	0.0396 mL	0.1978 mL	0.3956 mL	1.9778 mL
100 mM	0.0198 mL	0.0989 mL	0.1978 mL	0.9889 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc