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Quinupristin-Dalfopristin Complex (mesylate)

Name: Quinupristin-Dalfopristin Complex (mesylate)
Brand: TargetMol
SKU: TP2285
Rating: 4.5 (1 reviews)

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Catalog No. TP2285

Quinupristin-Dalfopristin Complex is a mixture of two streptogramin antibiotics. Quinupristin-dalfopristin complex is a mixture of two streptogramin antibiotics, dalfopristin, and quinupristin. Streptogramin antibiotics are divided into types A and B, which in combination can act synergistically.

Quinupristin-Dalfopristin Complex (mesylate)

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Catalog No. TP2285

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Quinupristin-Dalfopristin Complex is a mixture of two streptogramin antibiotics. Quinupristin-dalfopristin complex is a mixture of two streptogramin antibiotics, dalfopristin, and quinupristin. Streptogramin antibiotics are divided into types A and B, which in combination can act synergistically.
In vitro	In vitro: A previous study compared the molecular interactions of the streptogramin combinations Synercid (type A, dalfopristin; type B, quinupristin) and NXL 103 (type A, flopristin; type B, linopristin) with the Escherichia coli 70S ribosome. Results showed that the streptogramin A and B components in Synercid and NXL 103 exhibited synergistic antimicrobial activity against certain pathogenic bacteria. Moreover, in transcription-coupled translation assays, only combinations including dalfopristin, the streptogramin A component of Synercid, showed synergy [1].
In vivo	In vivo: A previous animal study aimed to investigate the efficacy of quinupristin/dalfopristin in the prevention of prosthetic graft infection in a rat subcutaneous pouch model. Results showed that quinupristin/dalfopristin had significantly higher efficacy than levofloxacin and doxycycline. In addition, only the group treated with quinupristin/dalfopristin combined with levofloxacin or doxycycline showed no evidence of staphylococcal infection [2].

Chemical Properties

Molecular Weight	1905.3
Formula	C₃₄H₅₁N₄O₉S[CH₃SO₃]·C₅₃H₆₈N₉O₁₀S[CH₃SO₃]
Smiles	O=C6C[C@@]5([H])C(=O)N[C@@]([H])(C1=CC=CC=C1)C(=O)O[C@@](C)([H])[C@]([H])(NC(=O)C=2N=CC=CC=2O)C(=O)N[C@]([H])(CC)C(=O)N3CCC[C@@]3([H])C(=O)N(C)[C@@]([H])(C/C4=C/C=C(C=C4)N(C)C)C(=O)N5C[C@@]6([H])C[S][C@]7([H])C[N+]8CC[C@]7([H])CC8.C[S]([O-])(=O)=O.O=C2C=C[C@](C)([H])[C@]([H])(OC(=O)[C@]1([H])N(CC[C@@]1([H])[S](=O)(=O)CC[N+](CC)CC)C(=O)C3=COC(CC(=O)C[C@@](O)([H])C=C(C)C=CCN2)=N3)C(C)(C)[H].C[S]([O-])(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble Ethanol: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

QuinupristinDalfopristin Complex (mesylate)Quinupristin-Dalfopristin ComplexQuinupristin Dalfopristin Complex (mesylate)

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