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Dehydro Nifedipine
🥰Excellent
Catalog No. T36665Cas No. 67035-22-7
Alias BAY-b 4759
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
Dehydro Nifedipine
🥰Excellent
Purity: 99.51%
Catalog No. T36665Alias BAY-b 4759Cas No. 67035-22-7
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | - | In Stock | |
| 10 mg | $64 | - | In Stock | |
| 25 mg | $129 | - | In Stock | |
| 50 mg | $208 | - | In Stock | |
| 100 mg | $333 | - | In Stock | |
| 200 mg | $498 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.51%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. |
| Targets&IC50 | Glucose uptake:130 μM |
| In vitro | Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM[1]. |
| Synonyms | BAY-b 4759 |
| Molecular Weight | 344.32 |
| Formula | C17H16N2O6 |
| Cas No. | 67035-22-7 |
| Smiles | COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c1ccccc1[N+]([O-])=O |
| Relative Density. | 1.284 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol: 2.7 mg/mL (7.84 mM), Sonication is recommended. DMSO: 27 mg/mL (78.42 mM), Sonication is recommended. DMF: 30 mg/mL (87.13 mM), Sonication is recommended. DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL (0.29 mM), Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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