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Fmoc-Gly3-Val-Cit-PAB

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Catalog No. T77828Cas No. 2647914-09-6

Fmoc-Gly3-Val-Cit-PAB is a cleavable linker used in the assembly of antibody-drug conjugates (ADCs).

Fmoc-Gly3-Val-Cit-PAB

Fmoc-Gly3-Val-Cit-PAB

😃Good
Catalog No. T77828Cas No. 2647914-09-6
Fmoc-Gly3-Val-Cit-PAB is a cleavable linker used in the assembly of antibody-drug conjugates (ADCs).
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2 mg$385 days5 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Fmoc-Gly3-Val-Cit-PAB is a cleavable linker used in the assembly of antibody-drug conjugates (ADCs).
In vitro
ADCs (Antibody-Drug Conjugates) consist of an antibody that is connected to an ADC cytotoxin via an ADC linker [1].
Chemical Properties
Molecular Weight772.85
FormulaC39H48N8O9
Cas No.2647914-09-6
SmilesC(OC(NCC(NCC(NCC(N[C@H](C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)[C@H](C)C)=O)=O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ADCLinkerADC Linker
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