Shopping Cart

Your shopping cart is currently empty

FCE 28073

Name: FCE 28073
Brand: TargetMol
SKU: T67850
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T67850Cas No. 174756-44-6

FCE 28073 is a Monoamine oxidase B inibitor with IC50 of 0.45 uM.

FCE 28073

Copy Product Info

🥰Excellent

Purity: 99.92%

Catalog No. T67850Cas No. 174756-44-6

FCE 28073 is a Monoamine oxidase B inibitor with IC50 of 0.45 uM.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	$79	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

FCE 28073 AI Summary

FCE 28073 exhibits potent anticonvulsant activities, indicated by its effectiveness in various seizure tests in mice: an ED50 of 26.9 mg/kg in the intravenous BIC test, 8.0 mg/kg in the maximal electroshock (MES) test, 60.6 mg/kg in the PTX test, 21.5 mg/kg in the 3-MPA test, and 104.1 mg/kg in the STRY test. When administered orally, it demonstrates significant anticonvulsant activity with an ED50 of 7.2 mg/kg before MES induction. The compound also shows bioactivity in inhibiting neurotransmitter binding. It inhibits [3H]batrachotoxin binding to rat brain sodium channels (IC50 of 8500.0 nM) but does not significantly affect [3H]saxitoxin binding (IC50 > 300,000.0 nM). It inhibits [3H]pentazocine binding to the sigma-1 opioid receptor with an IC50 of 280.0 nM. For the inhibition of rat brain mitochondria, it indicates IC50 values of 450.0 nM for MAOB and 42,000.0 nM for MAOA, showing a selectivity index of 93.0 for MAOB over MAOA. In terms of toxicity, FCE 28073 has a TD50 of 626.0 mg/kg in the rotarod neurological impairment test, though another source mentions a slightly different TD50 value of 584.0 mg/kg. The protective index, based on the ratio of TD50 to the anticonvulsant ED50, is calculated to be around 87.8 to 88.0, suggesting a relatively favorable safety profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	FCE 28073 is a Monoamine oxidase B inibitor with IC50 of 0.45 uM.
Targets&IC50	MAO-B:0.45 μM

Chemical Properties

Molecular Weight	302.34
Formula	C₁₇H₁₉FN₂O₂
Cas No.	174756-44-6
Smiles	O(CC1=CC(F)=CC=C1)C2=CC=C(CN[C@@H](C(N)=O)C)C=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (82.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3075 mL	16.5377 mL	33.0753 mL	165.3767 mL
5 mM	0.6615 mL	3.3075 mL	6.6151 mL	33.0753 mL
10 mM	0.3308 mL	1.6538 mL	3.3075 mL	16.5377 mL
20 mM	0.1654 mL	0.8269 mL	1.6538 mL	8.2688 mL
50 mM	0.0662 mL	0.3308 mL	0.6615 mL	3.3075 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc