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OVA Peptide (323-339)
🥰Excellent
Catalog No. T78000Cas No. 92915-79-2
OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.
OVA Peptide (323-339)
🥰Excellent
Purity: 99.38%
Catalog No. T78000Cas No. 92915-79-2
OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $54 | In Stock |
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Purity:99.38%
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Product Introduction
Bioactivity
Chemical Properties
| Description | OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice. |
| In vitro | At low concentrations (0.01 μM), OVA Peptide (323-339) enhances the ability of M2Y-type B cells to activate Th cells, more so than M2-type B cells[1]. |
| In vivo | OVA Peptide (323-339) is widely used in BALB/c mouse models to induce allergic immune responses. Repeated exposure results in enhanced production of OVA-specific IgE and Th2 cytokines, making it a potent tool for modeling antigen-specific hypersensitivity and allergy-related immune activation [2]. |
| Molecular Weight | 1773.9 |
| Formula | C74H120N26O25 |
| Cas No. | 92915-79-2 |
| Smiles | [C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CO)=O)CCC(N)=O)=O)C)=O)[C@H](C)C)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)C)=O)CCC(O)=O)=O)CC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)C)=O)=O)C)=O)C)=O |
| Sequence | Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg |
| Sequence Short | ISQAVHAAHAEINEAGR |
Storage & Solubility Information
| Storage | keep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: 8 mg/mL (4.51 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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