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OVA Peptide (323-339)

🥰Excellent
Catalog No. T78000Cas No. 92915-79-2

OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.

OVA Peptide (323-339)

OVA Peptide (323-339)

🥰Excellent
Purity: 99.38%
Catalog No. T78000Cas No. 92915-79-2
OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.
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1 mg$54In Stock
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Purity:99.38%
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Product Introduction

Bioactivity
Description
OVA Peptide (323-339) is an immunodominant epitope peptide derived from chicken ovalbumin (OVA), which is the major MHC class II-restricted T-cell epitope that specifically binds H2-IAd molecules, and a B-cell epitope that is recognized by IgE antibodies. It is commonly used in the study of egg allergy, and is able to induce strong Th2-type immune responses and IgE antibody production in mice.
In vitro
At low concentrations (0.01 μM), OVA Peptide (323-339) enhances the ability of M2Y-type B cells to activate Th cells, more so than M2-type B cells[1].
In vivo
OVA Peptide (323-339) is widely used in BALB/c mouse models to induce allergic immune responses. Repeated exposure results in enhanced production of OVA-specific IgE and Th2 cytokines, making it a potent tool for modeling antigen-specific hypersensitivity and allergy-related immune activation [2].
Chemical Properties
Molecular Weight1773.9
FormulaC74H120N26O25
Cas No.92915-79-2
Smiles[C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CO)=O)CCC(N)=O)=O)C)=O)[C@H](C)C)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)C)=O)CCC(O)=O)=O)CC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)C)=O)=O)C)=O)C)=O
Storage & Solubility Information
Storagekeep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 8 mg/mL (4.51 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.5637 mL2.8186 mL5.6373 mL28.1865 mL

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