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N-Desmethyl Pimavanserin

Name: N-Desmethyl Pimavanserin
Brand: TargetMol
SKU: T37979
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37979Cas No. 639863-77-7

Alias AC-279

N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia.

N-Desmethyl Pimavanserin

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Purity: 98.02%

Catalog No. T37979Alias AC-279Cas No. 639863-77-7

N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	-	In Stock
2 mg	$119	In Stock	In Stock
5 mg	$278	In Stock	In Stock
10 mg	$397	-	In Stock
25 mg	$669	-	In Stock
1 mL x 10 mM (in DMSO)	$253	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.02%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia.
In vitro	For Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279), the mean plasma half-lives are 57 hours and 200 hours, respectively.
Synonyms	AC-279

Chemical Properties

Molecular Weight	413.53
Formula	C₂₄H₃₂FN₃O₂
Cas No.	639863-77-7
Smiles	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (120.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4182 mL	12.0910 mL	24.1820 mL	120.9102 mL
5 mM	0.4836 mL	2.4182 mL	4.8364 mL	24.1820 mL
10 mM	0.2418 mL	1.2091 mL	2.4182 mL	12.0910 mL
20 mM	0.1209 mL	0.6046 mL	1.2091 mL	6.0455 mL
50 mM	0.0484 mL	0.2418 mL	0.4836 mL	2.4182 mL
100 mM	0.0242 mL	0.1209 mL	0.2418 mL	1.2091 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc