2'-deoxyadenosine

2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Key steps in nucleotide biosynthesis are regulated by feedback inhibitionBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.DNA is replicated by polymerases that take instructions from templatesBiochemistry(2002) 3.Cadwell, R.C., and Joyce, G.F.Randomization of genes by PCR mutagenesisPCR Methods Appl.2(1)28-33(1992) 4.Steffens, D.L., Jang, G.Y., Sutter, S.L., et al.An infrared fluorescent dATP for labeling DNAGenome Res.5(4)393-399(1995) 5.Flinn, A.M., and Gennery, A.R.Adenosine deaminase deficiency: A reviewOrphanet J. Rare Dis.13(1)65(2018)

2'-Chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2'-Modified nucleoside.

2-Bromo-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2-Modified purine nucleoside; Scaffold and Template.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyadenosine is a Nucleoside Derivative - Protected nucleoside with NH2/OH open.

3'-O-(t-Butyldimethylsilyl)-2'-deoxyadenosine is a Nucleoside Derivative - Protected nucleoside with NH2/OH group open.

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside

2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, demonstrates potent activity against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity.

N6-Etheno 2'-deoxyadenosine is used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.

3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM. This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

2'-Deoxyadenosine-5'-triphosphate-d14 (dATP-d14) dilithium is a deuterium-labeled version of 2'-Deoxyadenosine-5'-triphosphate. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), is employed in cells for DNA synthesis or replication and acts as a substrate for DNA polymerase.

2'-Deoxyadenosine-5'-triphosphate-15N5 (dATP-15N5) dilithium is a version of 2'-Deoxyadenosine-5'-triphosphate that is labeled with nitrogen-15 (15N). This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), plays a crucial role in cellular processes as it is utilized in DNA synthesis or replication. Additionally, 2'-Deoxyadenosine-5'-triphosphate (dATP) serves as a substrate for DNA polymerase.

2'-Deoxyadenosine-13C10 is a 13C-labeled version of 2'-Deoxyadenosine. This nucleoside adenosine derivative can pair with deoxythymidine in double-stranded DNA.

2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 (dATP-13C10,15N5) dilithium is the isotope-labeled form of 2'-Deoxyadenosine-5'-triphosphate with 13C and 15N. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), plays a critical role in cells for DNA synthesis and replication, serving as a substrate for DNA polymerases.

2'-Deoxyadenosine-5'-monophosphate-d12dilithium is the deuterium-labeled version of 2'-Deoxyadenosine-5'-monophosphate. This compound, a derivative of nucleic acid AMP, is a deoxyribonucleotide found in DNA. It is utilized in the study of adenosine-based interactions during DNA synthesis and damage processes.

2'-Deoxyadenosine-5'-triphosphate-13C10 (dATP-13C10) dilithium is a 13C-labeled form of 2'-Deoxyadenosine-5'-triphosphate. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), is utilized in cellular processes for DNA synthesis or replication and serves as a substrate for DNA polymerase.

2-Methoxy-2'-deoxyadenosine is a Nucleoside Derivative - 2-Modified purine nucleoside.

8-Bromo-2'-deoxyadenosine is a 2'-deoxynucleoside and halo-nucleoside.

N6-Benzoyl-2'-chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2'-Modified nucleoside.

8-Chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside, 8-Modified purine nucleoside.

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine is a nucleoside derivative with an open NH2/OH group.

N6-Isopentenyl-2'-deoxyadenosine is a Nucleoside Derivative - 6-Modified purine nucleoside.

2-Methyl-2'-deoxyadenosine is a Nucleoside Derivative - 2-Modified purine nucleoside.

8-Methyl-2'-deoxyadenosine is a Nucleoside Derivative - 8-Modified purine nucleoside.