Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 35 days | $ 158.00 | |
50 mg | 35 days | $ 265.00 | |
100 mg | 35 days | $ 488.00 | |
250 mg | 35 days | $ 748.00 |
Description | (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time. |
Molecular Weight | 217.02 |
Formula | C6H5BrN2O2 |
CAS No. | 69304-49-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 60 mg/mL
PBS (pH 7.2): 8 mg/mL
DMSO: 53 mg/mL
Ethanol: 0.8 mg/mL
You can also refer to dose conversion for different animals. More
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(E)-5-(2-Bromovinyl)uracil 69304-49-0 (E) 5 (2 Bromovinyl)uracil (E)5(2Bromovinyl)uracil 5-(2-Bromovinyl)uracil inhibitor inhibit