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2',4,4',6'-Tetramethoxychalcone
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Catalog No. TN7069Cas No. 94103-36-3
2',4,4',6'-Tetramethoxychalcone is a natural product.
2',4,4',6'-Tetramethoxychalcone
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Purity: 99.88%
Catalog No. TN7069Cas No. 94103-36-3
2',4,4',6'-Tetramethoxychalcone is a natural product.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $81 | - | In Stock | |
| 5 mg | $197 | - | In Stock | |
| 10 mg | $298 | - | In Stock | |
| 25 mg | $475 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.88%
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Product Introduction
2',4,4',6'-Tetramethoxychalcone AI Summary
2',4,4',6'-Tetramethoxychalcone is a bioactive molecule exhibiting multiple pharmacological and biological activities. It inhibits the production of Interleukin-1-beta from human peripheral blood monocytes when stimulated with lipopolysaccharide (LPS) with an IC50 value of 4600.0 nM. Additionally, it inhibits LPS-induced nitric oxide production in mouse RAW264.7 cells, with an IC50 of 15200.0 nM, and displays cytotoxicity against these cells, achieving 100.0% activity at 15.20 µM as assessed by an MTT assay.
Moreover, 2',4,4',6'-Tetramethoxychalcone has been shown to deter feeding behavior in Spodoptera litura, with a potent median effective dose (ED50) of 6.28 and 5.2 x 10^-7 mol/cm^2 in a Choice Leaf-Disk Bioassay using fresh sweet potato leaves. It also exhibits cytotoxic effects on human cell lines including HeLa, A549, and HepG2, with IC50 values of 19600.0 nM, 46600.0 nM, and 13500.0 nM, respectively, after 72 hours as measured by the MTT assay.
In terms of antiinvasive activity, 2',4,4',6'-Tetramethoxychalcone inhibits the progressive occupation of chicken pre-cultured heart tissue fragments by human MCF7/6 cells with a minimum concentration (Cmin) of 10.0 µmol/L as determined by the chick heart invasion assay over an 8-day period.
Furthermore, 2',4,4',6'-Tetramethoxychalcone shows cytotoxicity across a range of human cell lines, including HuH7, Caco2, MDA-MB-231, HCT116, PC3, NCI-H727, HaCaT, and fibroblasts. At a concentration of 50 µM after 48 hours, cell survival percentages vary from 14.0% to 62.0% relative to control, measured by the Hoechst 33342 staining assay, underscoring its potential as a broad-spectrum cytotoxic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 2',4,4',6'-Tetramethoxychalcone is a natural product. |
| Molecular Weight | 328.36 |
| Formula | C19H20O5 |
| Cas No. | 94103-36-3 |
| Smiles | C(/C=C/C1=CC=C(OC)C=C1)(=O)C2=C(OC)C=C(OC)C=C2OC |
| Relative Density. | 1.148 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (152.27 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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