Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydroisopimaric acid activates BK channels alphabeta1, which are large conductance Ca 2+ activated K + channels. This compound directly measures the opening of BKalphabeta1 under a whole-cell voltage clamp.
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Description | Dihydroisopimaric acid activates BK channels alphabeta1, which are large conductance Ca 2+ activated K + channels. This compound directly measures the opening of BKalphabeta1 under a whole-cell voltage clamp. |
In vitro | The impact of these compounds (10 microM) on the membrane potential of HEKBKalphabeta1 was assessed using DiBAC(4)(3), a voltage-sensitive dye. Dihydroisoparinic acid was observed to significantly induce membrane hyperpolarization. Moreover, within the concentration range of 1-10 microM, dihydroisopimaric acid effectively activates BKalphabeta1, as confirmed by the direct observation of BKalphabeta1 channel openings under whole-cell voltage clamp[1]. |
Molecular Weight | 304.474 |
Formula | C20H32O2 |
CAS No. | 5673-36-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Dihydroisopimaric acid 5673-36-9 inhibitor inhibit