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Amthamine 2HCl

Name: Amthamine 2HCl
Brand: TargetMol
SKU: T50112
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50112Cas No. 136604-58-5

Alias 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine 2HCl

5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine dihydrochloride is a potent and selective antagonist of metabotropic glutamate receptor 5 (mGluR5). It has been shown to be effective in several neurological disorders, including fragile X syndrome, autism spectrum disorders, and addiction.

Amthamine 2HCl

🥰Excellent

Purity: 98.61%

Catalog No. T50112Alias 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine 2HClCas No. 136604-58-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	In Stock	In Stock
5 mg	$298	In Stock	In Stock
10 mg	$433	In Stock	In Stock
25 mg	$678	In Stock	In Stock
50 mg	$912	In Stock	In Stock
100 mg	$1,180	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.61%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine dihydrochloride is a potent and selective antagonist of metabotropic glutamate receptor 5 (mGluR5). It has been shown to be effective in several neurological disorders, including fragile X syndrome, autism spectrum disorders, and addiction.
Synonyms	5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine 2HCl

Chemical Properties

Molecular Weight	230.159
Formula	C₆H₁₃Cl₂N₃S
Cas No.	136604-58-5
Smiles	Cl.Cl.Cc1nc(N)sc1CCN
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 14.67 mg/mL (63.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3448 mL	21.7241 mL	43.4482 mL	217.2411 mL
5 mM	0.8690 mL	4.3448 mL	8.6896 mL	43.4482 mL
10 mM	0.4345 mL	2.1724 mL	4.3448 mL	21.7241 mL
20 mM	0.2172 mL	1.0862 mL	2.1724 mL	10.8621 mL
50 mM	0.0869 mL	0.4345 mL	0.8690 mL	4.3448 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

5(2aminoethyl)4methyl1,3thiazol2amine dihydrochloride5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine5 (2 aminoethyl) 4 methyl 1,3 thiazol 2 amine dihydrochloride