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JAK2-IN-6

Name: JAK2-IN-6
Brand: TargetMol
SKU: T40443
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40443Cas No. 353512-04-6

Alias JAK2-IN-6

JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.

JAK2-IN-6

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Purity: 99.64%

Catalog No. T40443Alias JAK2-IN-6Cas No. 353512-04-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$108	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$289	In Stock	In Stock
100 mg	$428	In Stock	In Stock
200 mg	$623	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.
Targets&IC50	JAK2:22.86 μg/mL
In vitro	The treatment of JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours) demonstrates significant antiproliferative activity against PC-9, H1975, and PANC-1 cell lines. The IC50 values for PC-9, H1975, and PANC-1 cell lines are 18.1 μg/mL, 58.3 μg/mL, and 40.6 μg/mL, respectively [1].
Synonyms	JAK2-IN-6

Chemical Properties

Molecular Weight	335.83
Formula	C₁₄H₁₀ClN₃OS₂
Cas No.	353512-04-6
Smiles	Nc1nc(Nc2ccccc2)sc1C(=O)c1ccc(Cl)s1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (163.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9777 mL	14.8885 mL	29.7770 mL	148.8849 mL
5 mM	0.5955 mL	2.9777 mL	5.9554 mL	29.7770 mL
10 mM	0.2978 mL	1.4888 mL	2.9777 mL	14.8885 mL
20 mM	0.1489 mL	0.7444 mL	1.4888 mL	7.4442 mL
50 mM	0.0596 mL	0.2978 mL	0.5955 mL	2.9777 mL
100 mM	0.0298 mL	0.1489 mL	0.2978 mL	1.4888 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc