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IL-4R alpha Protein, Mouse, Recombinant (hFc)
(Synonyms: Soluble IL-4R-α, Soluble IL-4R-alpha, Interleukin-4 receptor subunit α, Interleukin-4 receptor subunit alpha, IL-4R-α, IL-4R-alpha, IL4-BP, CD124) Copy Product InfoSynonyms: Soluble IL-4R-α, Soluble IL-4R-alpha, Interleukin-4 receptor subunit α, Interleukin-4 receptor subunit alpha, IL-4R-α, IL-4R-alpha, IL4-BP, CD124
Catalog No. TMPJ-00387 Copy Product Info
Purity: 98.8%
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $46 | 7-10 days | 7-10 days | |
| 10 μg | $71 | - | In Stock | |
| 20 μg | $109 | 7-10 days | 7-10 days | |
| 50 μg | $197 | 7-10 days | 7-10 days | |
| 100 μg | $318 | 7-10 days | 7-10 days | |
| 200 μg | $523 | 7-10 days | 7-10 days | |
| 500 μg | $1,010 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.8%
Appearance:Lyophilized powder
Color:White
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| Description | Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P16382 |
| Amino Acid | Ile26-Arg233 |
| Construction | Ile26-Arg233 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) https://cdn.targetmol.com/group3/M00/13/6A/CgoaEWZG0zuETgdQAAAAAF8mh58050.png |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Soluble IL-4R-α, Soluble IL-4R-alpha, Interleukin-4 receptor subunit α, Interleukin-4 receptor subunit alpha, IL-4R-α, IL-4R-alpha, IL4-BP, CD124 |
| Research Background |
| Molecular Weight | 65-80 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: IL-4R alpha Protein, Mouse, Recombinant (hFc) chemical structure | IL-4R alpha Protein, Mouse, Recombinant (hFc) molecular weight
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