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AVG-233

Name: AVG-233
Brand: TargetMol
SKU: T63253
Rating: 4.5 (1 reviews)

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Catalog No. T63253Cas No. 2151937-80-1

AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.

AVG-233

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Purity: 99%

Catalog No. T63253Cas No. 2151937-80-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.
In vitro	AVG-233 (20 μM) exhibits nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates[1].
In vivo	In female Balb/cJ mice with recRSV-mKate xenograft, AVG-233 (50 and 100 mg/kg; oral gavage; once) reduced lung viral load by 0.89 log10 TCID50 (median tissue culture infectious dose)/mL[2].

Chemical Properties

Molecular Weight	487.94
Formula	C₂₆H₂₂ClN₅O₃
Cas No.	2151937-80-1
Smiles	COc1ccc(Cn2n(-c3ccccn3)c(=O)c3c(C)n(Cc4cccc(Cl)n4)c(=O)cc23)cc1

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (61.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0494 mL	10.2472 mL	20.4943 mL	102.4716 mL
5 mM	0.4099 mL	2.0494 mL	4.0989 mL	20.4943 mL
10 mM	0.2049 mL	1.0247 mL	2.0494 mL	10.2472 mL
20 mM	0.1025 mL	0.5124 mL	1.0247 mL	5.1236 mL
50 mM	0.0410 mL	0.2049 mL	0.4099 mL	2.0494 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc