Interferon alpha 2/IFNA2 Protein, Rhesus, Recombinant (His)

1. Measured in antiviral assay using WISH human amnion cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 0.4-4 pg/mL. 2. Measured by its binding ability in a functional ELISA. Immobilized Rhesus IFNA2-His at 10 μg/ml (100 μl/well) can bind human IFNAR2-Fc with a linear range of 0.31-2.5 μg/ml.

Interferon alpha 2/IFNA2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is B6CK11.

Rhesus

HEK293 Cells

> 90 % as determined by SDS-PAGE

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.