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2-Hydroxyflavanone

Name: 2-Hydroxyflavanone
Brand: TargetMol
SKU: T7984
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7984Cas No. 17348-76-4

2-Hydroxyflavanone is a naturally occurring flavonoid found in many plants and fruits. It has antioxidant, anti-inflammatory and anti-tumor activity, scavenging free radicals, reducing inflammation and inhibiting the growth of tumor cells. It also has the potential to treat a wide range of diseases including diabetes, obesity, cardiovascular disease and neurological disorders.

2-Hydroxyflavanone

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Purity: 99.97%

Catalog No. T7984Cas No. 17348-76-4

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
200 mg	$45	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

2-Hydroxyflavanone AI Summary

2-Hydroxyflavanone exhibits low binding affinity for adenosine receptors A1, A2A, and A3, as evidenced by its negative pKi values. In rat brain and striatal membranes, it displaces specific ligands with Ki values of 2640.0 nM for A1 and 17600.0 nM for A2 receptors, and in human HEK293 cells, it shows a Ki of 6070.0 nM for A3 receptors. Additionally, it demonstrates numerous bioactivities, including antioxidant activity in BALB/c mouse bone marrow cells with an IC25 value of 5620.0 uM and a pIC25 of -3.75, and inhibition of human recombinant 17beta-HSD1 and 17beta-HSD2 with activity levels of 95.0% and 50.7% respectively. 2-Hydroxyflavanone also modulates gene expression, increasing EGR1 mRNA expression in HEK293 cells at 20 ug/mL after 6 to 12 hours, with a fold-change (FC) value of 4.2. Furthermore, it shows a binding affinity to Enterococcus faecalis KAS3 and exhibits ABTS radical scavenging activity equivalent to 29.4 mg/L of vitamin C. As an enzyme inhibitor, 2-Hydroxyflavanone demonstrates potent inhibition of Acetylcholinesterase in rat cortex homogenates with an IC50 of 149.0 nM and inhibition of AKR1C3 with an IC50 of 100.0 nM. It also shows selectivity by inhibiting AKR1C2 over AKR1C3 with an IC50 ratio of 62.0. It inhibits nitric oxide, TNFalpha, and IL-1beta production in mouse RAW264.7 and J774A.1 cells with an IC50 of 71300.0 nM. In cell studies, 2-Hydroxyflavanone demonstrates antiproliferative activity against DU145, PC3, and LNCAP human cells with IC50 values of 4110.0 nM, 2560.0 nM, and 5450.0 nM, respectively. It antagonizes androgen receptor activity in LNCAP cells, reducing DHT-induced growth with an IC50 of 6400.0 nM. Moreover, 2-Hydroxyflavanone inhibits human recombinant AKR1C3 with an IC50 of 300.0 nM and human 11beta-HSD1 with an IC50 of 10000.0 nM. It has a dissociation constant (pKa) of 6.67, further contributing to its varied bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	240.25
Formula	C₁₅H₁₂O₃
Cas No.	17348-76-4
Smiles	Oc1ccccc1C1CC(=O)c2ccccc2O1
Relative Density.	1.288 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (104.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1623 mL	20.8117 mL	41.6233 mL	208.1165 mL
5 mM	0.8325 mL	4.1623 mL	8.3247 mL	41.6233 mL
10 mM	0.4162 mL	2.0812 mL	4.1623 mL	20.8117 mL
20 mM	0.2081 mL	1.0406 mL	2.0812 mL	10.4058 mL
50 mM	0.0832 mL	0.4162 mL	0.8325 mL	4.1623 mL
100 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0812 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc