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Isoderrone

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Catalog No. TN4279Cas No. 121747-89-5

Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may be a new drug for treatment of type 2 diabetes.

Isoderrone

Isoderrone

😃Good
Catalog No. TN4279Cas No. 121747-89-5
Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may be a new drug for treatment of type 2 diabetes.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may be a new drug for treatment of type 2 diabetes.
In vitro
METHODS AND RESULTS: Two new pyrrolidine alkaloids, ficushispimines A (1) and B (2), a new ω-(dimethylamino)caprophenone alkaloid, ficushispimine C (3), and a new indolizidine alkaloid, ficushispidine (4), together with the known alkaloid 5 and 11 known isoprenylated flavonoids 6 - 16, were isolated from the twigs of Ficus hispida. Their structures were elucidated by spectroscopic methods. CONCLUSIONS: Isoderrone (8), 3'-(3-methylbut-2-en-1-yl)biochanin A (11), myrsininone A (12), ficusin A (13), and 4',5,7-trihydroxy-6-[(1R*,6R*)-3-methyl-6-(1-methylethenyl)cyclohex-2-en-1-yl]isoflavone (14) showed inhibitory effects on α-glucosidase in vitro.
Chemical Properties
Molecular Weight336.34
FormulaC20H16O5
Cas No.121747-89-5
SmilesO=C1C(=COC=2C=C(O)C=C(O)C12)C=3C=CC=4OC(C=CC4C3)(C)C
Relative Density.1.368 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TyrosinaseIsoderrone
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