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Pachypodol

Name: Pachypodol
Brand: TargetMol
SKU: TN2032
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2032Cas No. 33708-72-4

Pachypodol, a methoxyflavonoid isolated from Pogostemon cablin Bentham, has antioxidant and cytoprotective properties and inhibits the growth of CaCo 2 colon cancer cell lines in vitro.Pachypodol protects neonatal rats from anesthesia-induced apoptosis in the developing brain through modulation of the JNK/ERK pathway.PDGFRα kinase inhibitory activity in macrophages exposed to STING agonists.

Pachypodol

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Purity: 99.82%

Catalog No. TN2032Cas No. 33708-72-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$289	-	In Stock
10 mg	$455	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:Yellow

Resource Download

COA CNMR HNMR HPLC MS

Product Introduction

Bioactivity

Description	Pachypodol, a methoxyflavonoid isolated from Pogostemon cablin Bentham, has antioxidant and cytoprotective properties and inhibits the growth of CaCo 2 colon cancer cell lines in vitro.Pachypodol protects neonatal rats from anesthesia-induced apoptosis in the developing brain through modulation of the JNK/ERK pathway.PDGFRα kinase inhibitory activity in macrophages exposed to STING agonists.
In vitro	Pachypodol, acting as a flavonol, is capable of inhibiting the growth of CaCo 2 colon cancer cell lines in vitro, and exhibits certain antioxidant and cytoprotective effects in HepG2 cells[1].

Chemical Properties

Molecular Weight	344.32
Formula	C₁₈H₁₆O₇
Cas No.	33708-72-4
Smiles	COc1cc(O)c2c(c1)oc(-c1ccc(O)c(OC)c1)c(OC)c2=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (232.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	145.2138 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	29.0428 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	14.5214 mL
20 mM	0.1452 mL	0.7261 mL	1.4521 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	2.9043 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc