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8-Hydroxyguanine
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Catalog No. T19165Cas No. 5614-64-2
Alias 8 Hydroxyguanine, 7,8-dihydro-8-oxoguanine, 2-Amino-6,8-dihydroxypurine
8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-Hydroxyguanine is mutagenic and carcinogenic and is commonly used in cancer experiments.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.
8-Hydroxyguanine
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Purity: 99.72%
Catalog No. T19165Alias 8 Hydroxyguanine, 7,8-dihydro-8-oxoguanine, 2-Amino-6,8-dihydroxypurineCas No. 5614-64-2
8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-Hydroxyguanine is mutagenic and carcinogenic and is commonly used in cancer experiments.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $64 | In Stock | In Stock | |
| 5 mg | $155 | In Stock | In Stock | |
| 10 mg | $228 | In Stock | In Stock | |
| 25 mg | $389 | In Stock | In Stock | |
| 50 mg | $573 | In Stock | In Stock | |
| 100 mg | $816 | - | In Stock | |
| 500 mg | $1,630 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.72%
Appearance:Solid
Color:Yellow
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Product Introduction
8-Hydroxyguanine AI Summary
8-Hydroxyguanine has shown notable bioactivity in two areas: as an inhibitor of Tau fibril formation with a potency of 39810.7 nM, and as an agonist at PSGR/OR51E2 with an extremely low EC50 value of 0.00044 nM. In its role as a PSGR/OR51E2 agonist, 8-Hydroxyguanine exhibits activity with a ratio of 0.57 relative to the control of 1 mM propionic acid, indicating potential in regulating the associated signaling pathway..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-Hydroxyguanine is mutagenic and carcinogenic and is commonly used in cancer experiments.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage. |
| Synonyms | 8 Hydroxyguanine, 7,8-dihydro-8-oxoguanine, 2-Amino-6,8-dihydroxypurine |
| Molecular Weight | 167.13 |
| Formula | C5H5N5O2 |
| Cas No. | 5614-64-2 |
| Smiles | NC1NC(C2=NC(NC2=N1)=O)=O |
| Relative Density. | 2.49g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble) H2O: 3.34 mg/mL (19.98 mM), when pH is adjusted to 11 with NaOH. Sonication and heating to 45℃ are recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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