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Lycobetaine acetate
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Catalog No. T8335Cas No. 61221-41-8
Alias Ungerimine acetate, Oxylycorine
Lycobetaine acetate (Oxylycorine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Ungeremine have strong antibacterial activity against Flavobacterium columnare
Lycobetaine acetate
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Purity: 99.84%
Catalog No. T8335Alias Ungerimine acetate, OxylycorineCas No. 61221-41-8
Lycobetaine acetate (Oxylycorine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Ungeremine have strong antibacterial activity against Flavobacterium columnare
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $38 | In Stock | In Stock | |
| 5 mg | $81 | In Stock | In Stock | |
| 10 mg | $117 | In Stock | In Stock | |
| 25 mg | $192 | In Stock | In Stock | |
| 50 mg | $283 | - | In Stock | |
| 100 mg | $418 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:Orange
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lycobetaine acetate (Oxylycorine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Ungeremine have strong antibacterial activity against Flavobacterium columnare |
| In vitro | Lycobetaine displayed cytotoxic activity towards the 9 cancer cell lines tested, including drug-sensitive and MDR phenotypes. The IC50values obtained varied from 3.67 μM (in MDA-MB-231-BCRP breast carcinoma cells) to 75.24 μM (against in CEM/ADR5000 leukemia cells) for Lycobetaine and from 0.02 μM (against CCRF-CEM cells) to 122.96 μM (against CEM/ADR5000 cells) for doxorubicin (control drug). Lycobetaine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1]. |
| Cell Research | The cytotoxicity, ferroptotic and necroptotic cell death were determined by the resazurin reduction assay. Caspase activation was evaluated using the caspase-Glo assay. Flow cytometry was applied for the analysis of cell cycle analysis (PI staining), apoptosis (annexin V/PI staining), mitochondrial membrane potential (MMP) (JC-1) and reactive oxygen species (ROS) (H2DCFH-DA). Apoptotic, necroptotic and autophagic markers were determined by Western blotting. CCRF-CEM leukemia cells were used for all mechanistic studies[1]. |
| Synonyms | Ungerimine acetate, Oxylycorine |
| Molecular Weight | 325.32 |
| Formula | C18H15NO5 |
| Cas No. | 61221-41-8 |
| Smiles | O=C([O-])C.OC1=CC2=C3C=C4OCOC4=CC3=C[N+]5=C2C(=C1)CC5 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | Ethanol: 1 mg/mL (3.07 mM), Sonication is recommended.  DMSO: < 1 mg/mL (insoluble or slightly soluble) H2O: Insoluble | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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