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BCAT-IN-2

Name: BCAT-IN-2
Brand: TargetMol
SKU: T35868
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35868Cas No. 1800024-45-6

BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia.

BCAT-IN-2

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Purity: 98.86%

Catalog No. T35868Cas No. 1800024-45-6

BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$121	In Stock	In Stock
25 mg	$221	In Stock	In Stock
50 mg	$298	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$92	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.86%

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COA HNMR LCMS MS

Product Introduction

Bioactivity

Description	BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia.
Targets&IC50	BCAT (rat, cytosolic):6.6 (pIC50), BCAT (rat, mitochondrial):7.39 (pIC50)
In vitro	BCAT-IN-2 inhibits BCATm in primary human adipocytes, with a pIC50 of 6.5[1].
In vivo	BCAT-IN-2 (5 mg/kg, po; 1 mg/kg, iv) exhibits favorable pharmacokinetic parameters in mice[1].

Chemical Properties

Molecular Weight	377.776
Formula	C₁₇H₁₄ClF₂N₅O
Cas No.	1800024-45-6
Smiles	CCCc1cc(=O)n2nc(NCc3c(F)cc(Cl)cc3F)c(C#N)c2[nH]1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (79.41 mM), Sonification is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.29 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6471 mL	13.2354 mL	26.4707 mL	132.3536 mL
5 mM	0.5294 mL	2.6471 mL	5.2941 mL	26.4707 mL
10 mM	0.2647 mL	1.3235 mL	2.6471 mL	13.2354 mL
20 mM	0.1324 mL	0.6618 mL	1.3235 mL	6.6177 mL
50 mM	0.0529 mL	0.2647 mL	0.5294 mL	2.6471 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc