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ACSS2-IN-2

🥰Excellent
Catalog No. T60060Cas No. 2332820-04-7
Alias MTB-9655

ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.

ACSS2-IN-2

ACSS2-IN-2

🥰Excellent
Purity: 99.5%
Catalog No. T60060Alias MTB-9655Cas No. 2332820-04-7
ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
2 mg$74In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$372In Stock
50 mg$578In Stock
100 mg$833In Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Purity:99.5%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.
In vitro
ACSS2-IN-2 (Compound 261) (5 h) exhibits ACSS2 inhibitory activity with an IC50 of 3.8 nM in MDA-MB-468 cells.'
SynonymsMTB-9655
Chemical Properties
Molecular Weight415.39
FormulaC21H19F2N3O4
Cas No.2332820-04-7
SmilesCOC(=O)c1cccc(c1)N1N=C(C)C(C(=O)Nc2cccc(c2)C(C)(F)F)C1=O
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (216.7 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4074 mL12.0369 mL24.0738 mL120.3688 mL
5 mM0.4815 mL2.4074 mL4.8148 mL24.0738 mL
10 mM0.2407 mL1.2037 mL2.4074 mL12.0369 mL
20 mM0.1204 mL0.6018 mL1.2037 mL6.0184 mL
50 mM0.0481 mL0.2407 mL0.4815 mL2.4074 mL
100 mM0.0241 mL0.1204 mL0.2407 mL1.2037 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MTB9655MTB 9655FattyAcidSynthaseFatty Acid SynthaseACSS2-IN-2ACSS2
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