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MM3122
MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
Catalog No. T60085Cas No. 2574390-27-3
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MM3122
Catalog No. T60085Cas No. 2574390-27-3
MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 2 mg | $119 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $319 | In Stock | |
| 25 mg | $597 | In Stock | |
| 50 mg | $866 | In Stock | |
| 100 mg | $1,160 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells. |
| In vitro | MM3122 (0-1 μM) exhibits inhibitory activity against HGFA, matriptase, hepsin, and thrombin with IC50 values of 32 nM, 0.31 nM, 0.19 nM, and over 20 nM, respectively. Additionally, MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3, and VSV-SARS CoV-2 chimera calu-3 with EC50 values of 74 nM, 0.87 nM, and 0.43 nM, respectively [1]. |
| In vivo | MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice[1]. |
| Alias | GTPL11533, MM-3122, Ac-GQFR-kbt |
| Molecular Weight | 665.76 |
| Formula | C31H39N9O6S |
| Cas No. | 2574390-27-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (135.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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