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MM3122

Name: MM3122
Brand: TargetMol
SKU: T60085
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60085Cas No. 2574390-27-3

Alias MM-3122, GTPL11533, Ac-GQFR-kbt

MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.

MM3122

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Purity: 99.83%

Catalog No. T60085Alias MM-3122, GTPL11533, Ac-GQFR-kbtCas No. 2574390-27-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$446	In Stock	In Stock
50 mg	$645	In Stock	In Stock
100 mg	$886	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
In vitro	MM3122 (0-1 μM) exhibits inhibitory activity against HGFA, matriptase, hepsin, and thrombin with IC50 values of 32 nM, 0.31 nM, 0.19 nM, and over 20 nM, respectively. Additionally, MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3, and VSV-SARS CoV-2 chimera calu-3 with EC50 values of 74 nM, 0.87 nM, and 0.43 nM, respectively [1].
In vivo	MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice[1].
Synonyms	MM-3122, GTPL11533, Ac-GQFR-kbt

Chemical Properties

Molecular Weight	665.76
Formula	C₃₁H₃₉N₉O₆S
Cas No.	2574390-27-3
Smiles	C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC(C)=O)=O)CCC(N)=O)=O)=O)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (135.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5020 mL	7.5102 mL	15.0204 mL	75.1021 mL
5 mM	0.3004 mL	1.5020 mL	3.0041 mL	15.0204 mL
10 mM	0.1502 mL	0.7510 mL	1.5020 mL	7.5102 mL
20 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7551 mL
50 mM	0.0300 mL	0.1502 mL	0.3004 mL	1.5020 mL
100 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.7510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc