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MM3122

Name: MM3122
Brand: TargetMol
SKU: T60085
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60085Cas No. 2574390-27-3

Alias MM-3122, GTPL11533, Ac-GQFR-kbt

MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.

MM3122

🥰Excellent

Purity: 99.83%

Catalog No. T60085Alias MM-3122, GTPL11533, Ac-GQFR-kbtCas No. 2574390-27-3

Pack Size	Price	Availability
1 mg	$73	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$446	In Stock
50 mg	$645	In Stock
100 mg	$886	In Stock

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Purity:99.83%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
In vitro	MM3122 (0-1 μM) exhibits inhibitory activity against HGFA, matriptase, hepsin, and thrombin with IC50 values of 32 nM, 0.31 nM, 0.19 nM, and over 20 nM, respectively. Additionally, MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3, and VSV-SARS CoV-2 chimera calu-3 with EC50 values of 74 nM, 0.87 nM, and 0.43 nM, respectively [1].
In vivo	MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice[1].
Synonyms	MM-3122, GTPL11533, Ac-GQFR-kbt

Chemical Properties

Molecular Weight	665.76
Formula	C₃₁H₃₉N₉O₆S
Cas No.	2574390-27-3
Smiles	C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC(C)=O)=O)CCC(N)=O)=O)=O)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (135.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5020 mL	7.5102 mL	15.0204 mL	75.1021 mL
5 mM	0.3004 mL	1.5020 mL	3.0041 mL	15.0204 mL
10 mM	0.1502 mL	0.7510 mL	1.5020 mL	7.5102 mL
20 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7551 mL
50 mM	0.0300 mL	0.1502 mL	0.3004 mL	1.5020 mL
100 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.7510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc