Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 83.00 | |
2 mg | In stock | $ 119.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 319.00 | |
25 mg | In stock | $ 597.00 | |
50 mg | In stock | $ 866.00 | |
100 mg | In stock | $ 1,160.00 |
Description | MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells. |
In vitro | MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively. MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3 and VSV-SARS CoV-2 chimera calu-3 with the EC50 values of 74, 0.87 nM and 0.43 respectively [1]. |
In vivo | MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice[1]. |
Synonyms | GTPL11533, MM-3122, Ac-GQFR-kbt |
Molecular Weight | 665.76 |
Formula | C31H39N9O6S |
CAS No. | 2574390-27-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (135.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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MM3122 2574390-27-3 Microbiology/Virology SARS-CoV GTPL11533 GTPL-11533 GTPL 11533 MM 3122 MM-3122 Ac-GQFR-kbt inhibitor inhibit