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VEGFR-2-IN-62

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Catalog No. T204422

VEGFR-2-IN-62 (Compound 3f) is a potent inhibitor of VEGFR-2, with an IC50 value of 0.0557 μM. It inhibits cell proliferation and induces apoptosis (Apoptosis), making it useful for cancer research.

VEGFR-2-IN-62

VEGFR-2-IN-62

😃Good
Catalog No. T204422
VEGFR-2-IN-62 (Compound 3f) is a potent inhibitor of VEGFR-2, with an IC50 value of 0.0557 μM. It inhibits cell proliferation and induces apoptosis (Apoptosis), making it useful for cancer research.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
VEGFR-2-IN-62 (Compound 3f) is a potent inhibitor of VEGFR-2, with an IC50 value of 0.0557 μM. It inhibits cell proliferation and induces apoptosis (Apoptosis), making it useful for cancer research.
Targets&IC50
VEGFR2:0.0557 μM
In vitro
VEGFR-2-IN-62 (Compound 3f) at 0.08 μM for 24 hours induces apoptosis in MCF-7 cells, significantly increasing Bax levels while decreasing Bcl2 levels, thereby greatly enhancing the Bax/Bcl2 ratio [1]. It exhibits antiproliferative activity against HepG2, MCF-7, and VERO human tumor cell lines with IC50 values of 0.17, 0.08, and 1.98 μM, respectively [1]. Additionally, VEGFR-2-IN-62 at 2.3 μM for 24 hours causes cell cycle arrest at the G2-M phase in MCF-7 cells [1].
Chemical Properties
Molecular Weight467.906
FormulaC26H18ClN5O2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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