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GoSlo-SR-5-69

Name: GoSlo-SR-5-69
Brand: TargetMol
SKU: T37294
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T37294 Copy Product Info

Purity: 99.73%

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GoSlo-SR-5-69 is a potent high-conductance calcium-activated potassium channel (BK channel) agonist, with an EC50 of 251 nM. GoSlo-SR-5-69 significantly shifts the voltage required for half-maximal activation in a negative direction (ΔV1/2 = −104 mV), thereby enhancing channel open probability. Widely used in studies of neuronal excitability, vasodilation, smooth muscle regulation, and ion channel pharmacology, it elucidates BK channel function under physiological and pathological conditions.

GoSlo-SR-5-69

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Catalog No. T37294

Cas No. 1363419-31-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$71	-	In Stock
5 mg	$172	-	In Stock
10 mg	$263	-	In Stock
25 mg	$529	-	In Stock
50 mg	$757	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.73%

Appearance:Solid

Color:Black

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	470.47
Formula	C₂₄H₁₉N₂NaO₅S
Cas No.	1363419-31-1
Smiles	O=C1C2=C(C(C3=C(NC4=CC=C5C(CCCC5)=C4)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (85.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1255 mL	10.6277 mL	21.2553 mL	106.2767 mL
5 mM	0.4251 mL	2.1255 mL	4.2511 mL	21.2553 mL
10 mM	0.2126 mL	1.0628 mL	2.1255 mL	10.6277 mL
20 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3138 mL
50 mM	0.0425 mL	0.2126 mL	0.4251 mL	2.1255 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc