Reserpine hydrochloride （Serpivite hydrochloride） is the salt form of Reserpine, an alkaloid that inhibits the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral axon terminals, with antihypertensive and antipsychotic potential.

In JB6 P+ and HepG2-C8 cells, Reserpine hydrochloride (2.5–10 μM; 7 days) was used to evaluate its regulatory effects on oxidative stress and epigenetic markers. Reserpine hydrochloride upregulated Nrf2, HO-1, and NQO1 protein expression, while downregulating mRNA levels of DNMT1, DNMT3a, and DNMT3b. [1] In clinical isolates of Staphylococcus aureus, Reserpine hydrochloride (20 mg/L) was used to assess its ability to inhibit the NorA efflux pump, reduce the MIC of ciprofloxacin, and enhance its antibacterial efficacy. [1]

In rats, Reserpine hydrochloride (0.2 mg/kg; i.p.; once daily for 14 days) was administered to induce a depression-like phenotype. 48 hours after withdrawal, reserpine significantly decreased immobility time and increased climbing behavior in the forced swim test, indicating adaptive changes in monoamine systems. [1] In rats, Reserpine hydrochloride (5 mg/kg; i.p.; single dose) was used to examine neurotransmitter turnover, which significantly increased urinary levels of vanillylmandelic acid (VMA) and 5-hydroxyindoleacetic acid (5-HIAA), indicating enhanced catecholamine and serotonin metabolism. [1] In rats, Reserpine hydrochloride (0.5–15 μg/kg; i.p.; single dose) was tested for its antihypertensive effect, which produced a dose-dependent reduction in blood pressure. [1]