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Reserpine hydrochloride

Name: Reserpine hydrochloride
Brand: TargetMol
SKU: T21772
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21772Cas No. 16994-56-2

Alias Serpivite hydrochloride, Serpasil hydrochloride, Serpalan hydrochloride

Reserpine hydrochloride is the salt form of Reserpine and acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2). It blocks the uptake of norepinephrine into storage vesicles, leading to the depletion of catecholamines and serotonin at central and peripheral nerve terminals. It has antihypertensive and antipsychotic properties and is commonly used to induce models of gastric ulcer and depression.

Reserpine hydrochloride

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Purity: 99.96%

Catalog No. T21772Alias Serpivite hydrochloride, Serpasil hydrochloride, Serpalan hydrochlorideCas No. 16994-56-2

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	-	In Stock
100 mg	$50	-	In Stock
500 mg	$119	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Reserpine hydrochloride is the salt form of Reserpine and acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2). It blocks the uptake of norepinephrine into storage vesicles, leading to the depletion of catecholamines and serotonin at central and peripheral nerve terminals. It has antihypertensive and antipsychotic properties and is commonly used to induce models of gastric ulcer and depression.
In vitro	In JB6 P+ and HepG2-C8 cells, Reserpine hydrochloride (2.5–10 μM; 7 days) was used to evaluate its regulatory effects on oxidative stress and epigenetic markers. Reserpine hydrochloride upregulated Nrf2, HO-1, and NQO1 protein expression, while downregulating mRNA levels of DNMT1, DNMT3a, and DNMT3b. [1] In clinical isolates of Staphylococcus aureus, Reserpine hydrochloride (20 mg/L) was used to assess its ability to inhibit the NorA efflux pump, reduce the MIC of ciprofloxacin, and enhance its antibacterial efficacy. [1]
In vivo	In rats, Reserpine hydrochloride (0.2 mg/kg; i.p.; once daily for 14 days) was administered to induce a depression-like phenotype. 48 hours after withdrawal, reserpine significantly decreased immobility time and increased climbing behavior in the forced swim test, indicating adaptive changes in monoamine systems. [1] In rats, Reserpine hydrochloride (5 mg/kg; i.p.; single dose) was used to examine neurotransmitter turnover, which significantly increased urinary levels of vanillylmandelic acid (VMA) and 5-hydroxyindoleacetic acid (5-HIAA), indicating enhanced catecholamine and serotonin metabolism. [1] In rats, Reserpine hydrochloride (0.5–15 μg/kg; i.p.; single dose) was tested for its antihypertensive effect, which produced a dose-dependent reduction in blood pressure. [1]
Disease Modeling Protocol	Gastric ulcer model Modeling Mechanism： Reserpine hydrochloride depletes catecholamine neurotransmitters in sympathetic nerve endings, causing vasoconstriction and reduced blood flow in the gastric mucosa, leading to mucosal ischemia and hypoxia. At the same time, it inhibits the synthesis of prostaglandins in the gastric mucosa, weakens the mucosal barrier function, and promotes gastric acid secretion, ultimately inducing gastric mucosal erosion, bleeding, and ulcer formation. Abnormal gastric artery contraction further aggravates insufficient mucosal blood supply and exacerbates ulcer progression. Related Products： Reserpine hydrochloride (T21772) Modeling Method： Experimental Subject：Rats, Sprague–Dawley (SD), Male, Body weight 200–230 g Dosage and Administration Route：Reserpine 0.5–1 mg/kg, dissolved in physiological saline or DMSO, intraperitoneal injection / subcutaneous injection; adrenocorticotropic hormone dissolved in physiological saline, 1 ml/kg injection (control group administered equal volume physiological saline) Dosing Frequency and Duration Model：Once daily for 7–14 consecutive days Validation： Multiple erosions and oval ulcer foci were observed in the gastric mucosa; the ulcer index was significantly elevated; the gastric artery contraction response was enhanced; the gastric mucosal PGE₂ level was decreased, and serum gastrin was elevated; pathology showed mucosal epithelial necrosis and inflammatory cell infiltration. Precautions： Rats were fasted for 36 hours before modeling (and water was withheld 1 hour before the experiment); rats were sacrificed 7-14 days after modeling. References：Salomone S,et,al. Effects of adrenomedullin on the contraction of gastric arteries during reserpine-induced gastric ulcer. Peptides. 2003 Jan;24(1):117-22.
Synonyms	Serpivite hydrochloride, Serpasil hydrochloride, Serpalan hydrochloride

Chemical Properties

Molecular Weight	645.14
Formula	C₃₃H₄₁ClN₂O₉
Cas No.	16994-56-2
Smiles	C(OC)(=O)[C@H]1[C@]2(C[C@@]3(C4=C(C=5C(N4)=CC(OC)=CC5)CCN3C[C@]2(C[C@@H](OC(=O)C6=CC(OC)=C(OC)C(OC)=C6)[C@@H]1OC)[H])[H])[H].Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 40 mg/mL (62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5501 mL	7.7503 mL	15.5005 mL	77.5026 mL
5 mM	0.3100 mL	1.5501 mL	3.1001 mL	15.5005 mL
10 mM	0.1550 mL	0.7750 mL	1.5501 mL	7.7503 mL
20 mM	0.0775 mL	0.3875 mL	0.7750 mL	3.8751 mL
50 mM	0.0310 mL	0.1550 mL	0.3100 mL	1.5501 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc